منابع مشابه
The sour taste of a proton current.
S our taste can be agreeable in moderation. However, most people respond to drinking lemon juice with a violent contortion of their faces that clearly signals to everybody around that a mouth free of acid is greatly preferred. Such a strong aversive response must be based on a reliable aciddetection system on the tongue. Emily Liman’s Laboratory of Sensory Neurobiology at the University of Sout...
متن کاملBortezomib alters sour taste sensitivity in mice
Chemotherapy-induced taste disorder is one of the critical issues in cancer therapy. Bortezomib, a proteasome inhibitor, is a key agent in multiple myeloma therapy, but it induces a taste disorder. In this study, we investigated the characteristics of bortezomib-induced taste disorder and the underlying mechanism in mice. Among the five basic tastes, the sour taste sensitivity of mice was signi...
متن کاملThe chemistry and physiology of sour taste--a review.
Sour taste is the key element in the flavor profile of food acidulants. Understanding the chemistry and physiology of sour taste is critical for efficient control of flavor in the formulation of acid and acidified foods. After a brief introduction to the main applications of food acidulants, several chemical parameters associated with sour taste are discussed. Special emphasis is given to hydro...
متن کاملSour taste finds closure in a potassium channel.
Taste cells in taste buds of the mammalian tongue and oral cavity can detect five basic modalities: sweet, bitter, umami, salty, and sour. Each taste cell expresses distinct molecular sensors, such as G protein-coupled receptors or ion channels, which detect tastants (i.e., chemical stimuli that elicit taste sensation) and initiate an intracellular response that culminates in membrane depolariz...
متن کاملSour Taste Responses in Mice Lacking PKD Channels
BACKGROUND The polycystic kidney disease-like ion channel PKD2L1 and its associated partner PKD1L3 are potential candidates for sour taste receptors. PKD2L1 is expressed in type III taste cells that respond to sour stimuli and genetic elimination of cells expressing PKD2L1 substantially reduces chorda tympani nerve responses to sour taste stimuli. However, the contribution of PKD2L1 and PKD1L3 ...
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ژورنال
عنوان ژورنال: QJM
سال: 2002
ISSN: 1460-2393
DOI: 10.1093/qjmed/95.3.181